In the present study, a novel series of 4-(2, 5-dimethyl-1H-pyrrol1-yl)-N'-(2-oxoindolin-3-ylidene) benzohydrazides have been synthesized in good yields and characterized by IR, NMR and mass spectral analyses. Compounds were evaluated for their preliminary in-vitro cytotoxic activity against HCT-116 (colon), MCF-7 (breast) and HepG2 (hepatocellular) cancer cell lines by standard MTT assay and also were screened for antioxidant activity standard DPPH assay method. Our results show that three of the analogues 7i, 7f and 7b are potent cytotoxic agents against all tumor cell lines assayed, showing significant IC50 values. The IC50 values of compounds 7i, 7f and 7b against MCF-7 were 32.07, 31.72, 34.25 μg/ml; against HCT-116 were 24.41, 21.25, 39.23 μg/ml and against HepG2 were 15.01, 29.23, 22.95 μg/ml, respectively, by comparing with positive control cisplatin (IC50 = 12. 18, = 23. 99 and =7. 23 μg/ml for HCT-116, MCF-7 and HepG2 respectively. Compound 7i was proved as potent antioxidant agent.
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